Learning Centre

X-Nuclei NMR Spectroscopy Part 2: Broadband Nuclei analysis with X-Pulse — Technical Article
IntroductionNMR spectroscopy is most commonly used to analyse hydrogen-1 (1H, proton), carbon-13 (13C) and fluorine-19 (19F) nuclei. However, most modern NMR spectrometers can observe many more nucle…
X-Nuclei NMR Spectroscopy Part 1: Introduction to Broadband NMR Spectroscopy — Technical Article
Introduction When the first commercial NMR instruments were introduced in the early 1950s, they could analyse a single nucleus: hydrogen-1 (1H, proton). Only many years later would commercial multi…
Myeloid Therapy: High-Resolution Insights into Brain Rescue — Webinars
Many neurodegenerative diseases share a common driver: the failure of the brain’s immune system. This research uncovers a pre-symptomatic "interferon alarm" that triggers progressive decline and ide…
SEM Failure Analysis of a Diesel Turbocharger: Why BEX Succeeds Where EDS Struggles — Application Notes
Key Message: BEX enables failure analysis where shadowing inhibits EDS—allowing compositional analysis of pristine fracture surfaces that hold vital root cause evidence.Turbocharger turbine blades op…
Extending SEM X-Ray Analysis with BEX: A Solution to X-Ray Shadowing — Application Notes
What is X-ray Shadowing and How Does It Limit SEM-EDS Analysis The study focuses on the chemical characterisation of particulate material captured by an in-line liquid chromatography filter, where …
Importing Objects into the Cell Module as a Workflow — Tutorials
Discover how to import objects into the Cell module within a Workflow to streamline cell-based analysis and maintain consistency across multiple datasets.
Object-Based Colocalization Options in Workflow — Tutorials
Learn how to use the Object-Based Colocalization options within a Workflow to analyze spatial relationships between detected objects and generate reproducible results across similar datasets.
Statistic Export Options — Tutorials
This tutorial demonstrates how to use the Statistics Export options in Workflows to efficiently save, organize, and review your analysis results for downstream processing and reporting.
Comparative Photometry with Marana CMOS and iKon-L CCD Cameras at the NGTS Facility — Technical Article
Recent laboratory and on-sky studies have shown that modern CMOS sensors can deliver high quality photometry across a range of astronomical applications [1, 2], with precision reaching the milli-magn…
Annealing of a Polymer Thin Film in Controlled Toluene Vapor on a Cypher ES AFM — Application Video
This video highlights a key advantage of the Cypher ES: its fully sealed, pressure‑tight sample chamber. Many AFMs allow gas purging during imaging—for example, using argon to prevent oxidation or …
Optical spectroscopy of organic molecules on metal surfaces and in solution — Application Notes
IntroductionPorphyrins are highly conjugated macrocycles, capable of coordinating metal ions at the central cavity. Owing to their tunable electronic structure and rich photophysics, they are central…
Thermomechanical Raman mapping of GaN HEMTs via temperature-induced phonon peak shifts — Application Notes
GaN-based high-electron-mobility transistors (HEMTs) require accurate, spatially resolved temperature measurements to assess device thermal behavior and reliability. This Application Note presents …
AZtec software 'Tips and Tricks' for Quantitative Microanalysis Analysis — Application Video
During our latest session from the EDS User Meeting, we shared practical guidance on: Reducing uncertainty in overlapped peak quantification Selecting the right process time…
Industrial Quality Control and Workflow Integration with the witec360 Platform — Application Notes
Pharmaceutical manufacturing requires analytical technologies that provide reliable chemical information while integrating seamlessly into industrial quality control workflows. Beyond research appl…
Particle Analysis Pushed to its Limits Characterising Sub-Resolution Limit Particles with ParticleScout and AFM — Application Notes
While microplastic analysis has become an established field of research, the characterisation of nanoplastics - polymer particles typically smaller than 1000 nm - remains a major analytical ch…
Stable Imaging of Polymer Melt and Recrystallization Dynamics During Continuous Temperature Ramping on a Cypher ES AFM — Application Video
This video demonstrates the exceptional performance and stability of the Cypher ES AFM during an experiment where a polymer blend wa…
10 things you didn’t know about EMCCD Cameras — Technical Article
Charge-coupled device (CCD) cameras laid the foundation for modern scientific imaging and defined standards for sensitivity and image quality across microscopy and spectroscopy for decades. This incl…
Advanced EDS Elemental Analysis in SEM using BEX: Materials Science and Batteries — Webinars
This webinar will cover the latest advancements in EDS and the innovative BEX detector and will showcase their effectiveness through real-world applications, including functiona…
Exceptional Environmental Control on Cypher and Vero AFMs — Application Video
The ES and VRS1250 models in the Cypher and Vero AFM families are designed from the ground up for exceptional environmental control. They are based on a fully sealed, pressure‑t…
Automated Workflow for Detecting and Characterizing Opaque Solid Inclusions in Transparent Mineral Separates — Application Notes
Executive Summary Solid inclusions within transparent host minerals such as zircon are known to record valuable information for geochronology, paleoenvironment, and provenance studies. Furthermore, …
Simplify Your Imaging: Complete Workflows from Acquisition to Analysis — Webinars
Join Megan as she walks you through the technologies she uses daily to help researchers overcome imaging challenges and accelerate their discoveries. With hands-on experience de…
Tabletop Automated Mineralogy: Increasing Accessibility without Compromising Speed — Application Notes
Automated mineralogy transformed the evaluation of ore mineralogy and texture by integrating the imaging capabilities of scanning electron microscopy (SEM) with the rapid chemical analysis of energy‑…
RISE Microscopy for Charging‑Stable, Raman‑True Correlative Analysis — Webinars
This webinar demonstrates how conductive coatings, VP‑SEM operation, and the AZtecRISE navigator in the latest 6.3 release bring these conditions together. These improvements en…
Scanning Capacitance Microscopy — Application Video
Scanning Capacitance Microscopy (SCM) is a powerful electrical characterization technique with broad applicability across a variety of fields such as semiconductors, failure ana…
Workflow for confocal Raman analysis of inclusions: What can we learn from inclusions in diamonds? — Application Notes
Inclusions – solids, liquids, or gases trapped within minerals during crystallization – are essential tools in geology. They act as natural “time capsules,” providing direct e…
AZtecCrystal 4.0 – New Features for In-situ Experiments and Quality Control — Webinars
This webinar introduces the new capabilities in AZtecCrystal 4.0, designed to make time‑lapse and in‑situ EBSD experiments faster, more synchronised and easier to analyse. With …
Fast Moiré Imaging with the Jupiter Discovery — Application Video
Imagine doing AFM, only many times faster. In an hour, you could collect a complete dataset that would normally take a week with conventional AFMs. See the difference in speed with Oxford Instrume…
Inside Out: Unlocking the Hidden Apical Surface of Organoids for High-Resolution Imaging — Webinars
Discover how LPA and S1P flip organoids apical-out, enabling high‑resolution imaging, long-term studies, and ECM‑free culture for clearer insights into tissue biology.
Versatile Raman solutions for tomorrow's challenges: Semiconductors, Materials, and Beyond — Webinars
Explore how modern Raman spectroscopy and confocal Raman microscopy enable fast, precise chemical and structural analysis across semiconductors, materials, chemistry, and life s…
Asbestos Analysis in the SEM with AZtecAsbestos — Application Notes
Introduction: Why is asbestos analysis crucial?  Asbestos is a material that was widely used in the mid-late 20th century as an insulator (in buildings, boilers, pipes, roofing a…
Capture the Moment – Track Steel Transformations with Crystal Batch & Compare — Application Notes
Understanding how microstructures evolve during phase transformations is essential for optimising the performance of structural materials such as high-strength steel products. Electron Backscatter Di…
Maximising Raman Spectroscopy Performance: Why Optimised Grating Selection Matters — Technical Article
In Raman spectroscopy, the choice of diffraction grating is far more than a technical detail, it’s a critical factor in achieving meaningful results. To unlock the full potential of your Raman …
Pushing the boundaries of Microanalysis in SEM with the BEX technique — Webinars
Ultra-Sensitive Blue & UV Detection with the iXon Ultra Blue EMCCD — Application Video
Join Colin Coates as he goes through the iXon Ultra Blue EMCCD, exploring its advanced design, ultra-sensitive blue and near-UV performance, and enhanced quantum efficiency. He explains how these c…
What Makes Vero AFMs Different? — Application Video
What makes the Vero AFM different from most other AFMs? Unlike conventional AFMs that must infer height from angular changes of the cantilever, the Vero AFM uses an interferometric detector to direc…
Comparative Performance of sCMOS and UV-Sensitive EMCCD Cameras for Advanced UV Imaging and Spectroscopy — Application Notes
High-sensitivity ultraviolet (UV) imaging and spectroscopy are essential for emerging applications such as optical characterization of high-bandgap semiconductors, photolithographic mask inspection, …
Ultrastructural Localization of Antigens in Tissues with Immunogold Labeling, Enzymatic Metallography and Elemental Analysis Using the BEX SEM Technique — Application Notes
Introduction Immuno‑electron microscopy (immuno‑EM) is a method for the fine localization and characterization of potential drug targets in tissues and for safety assessment studies of therapeutic…
Distribution and Identification of Nanoparticles in Cells using EDS — Application Notes
Aim To confirm the uptake and the subcellular localisation of thallium nanoparticles in cells and tissues for cancer therapy. Challenge When investigating the localisation of nanoparticles with el…
Rapid Failure Analysis of Structural Materials Using SEM-BEX: Ni-alloy Brittle Failure Case Study — Application Notes
Fast, Reliable Failure Analysis—Even with Large Unprepared Samples In industries where safety and performance are paramount, such as aerospace, automotive, and defense, understanding material …
Closing the Link: Resilient Free-Space Optical Communications with Transmissive Adaptive Optics — Application Notes
Global bandwidth demand is outstripping Radio Frequency (RF) spectrum capacity. Facing this “spectrum crunch”, operators are pivoting toward Free-Space Optical (FSO) communications. By ut…
RISE Microscopy for 2D Materials — Webinars
Due to their unique optical and electronic properties, two-dimensional (2D) materials have great potential for application in optoelectronic devices, sensors energy storage, cat…
Distinguishing ABA- and ABC-Stacked Trilayer Graphene with Atomic Force Microscopy — Application Notes
For few-layer 2D materials, stacking configuration can be an important degree of freedom for tuning physical properties. For example, trilayer graphene has two stable stacking sequences, ABA and ABC,…
Photonics and Optical Detectors - A to Z Glossary — Technical Article
A B C D E F G L N O P Q R S T U W X Z What is Accumulation? Accumulation is the process by which data acquired from a number of similar scans are added together in computer me…
KPFM Made Simple — Application Video
Kelvin Probe Force Microscopy (KPFM) is an AFM imaging mode which maps the work function of a sample surface while simultaneously imaging its topography. Many users could benefi…
Resolving Angle-Dependent Properties of Twisted Layers of 2D Materials Using AFM — Application Notes
Since the discovery of the unique properties and exotic physics of graphene, interest in it and other 2D materials and their layered structures has flourished. Graphene has excellent electrical and t…
Electrolyte Analysis with the X-Pulse — Application Notes
Introduction There is a growing importance in the use of automation in laboratory environments, for example the use of Materials Acceleration Platforms (MAPs), automating both experiments and subseq…
Intensified Fast Gated CMOS Technology for Dynamic Imaging of Supersonic and Hypersonic Flow Dynamics — Application Notes
Turbulent flows around supersonic and hypersonic vehicles are necessary to understand as they can lead to the degradation of the walls of spacecraft and high-altitude aircraft. Thus, characterizing m…
Graphene Cutting Using Anodic Oxidation Lithography — Application Video
Watch how easy it is to cut graphene with AFM using anodic oxidation lithography, a standard feature in our software. Graphene cutting can be used to make twisted bilayer graphe…
Andor CB2 Series Webinar — Webinars
Andor CB2 camera series is a brand new family of sCMOS cameras, designed to deliver outstanding performance and flexibility for advanced imaging applications. In this webinar, …
Performance Testing Andor's Marana 4.2B-11 sCMOS Camera — Application Notes
Based on Apergis et al. 2025, RASTI, 4, rzaf049 Complementary Metal–Oxide Semiconductor (CMOS) image sensors have been developed in parallel with Charge-Coupled Devices (CCDs) for decades, but…
Beating the Atmosphere: High-speed Wavefront Sensing for Resolved Space Situational Awareness — Application Notes
The orbital environment has reached a critical density. To manage the exponentially growing threat of space debris, operators rely on Space Situational Awareness (SSA) for collision avoidance. Howeve…
Developments in Infrared e-APD Wavefront Sensing Camera Technology — Technical Article
The planet-hunting astronomical instruments of tomorrow, which aim to discover Earth-like planets in nearby star systems by 2035, must be capable of delivering image contrast of order 109. Rapid and …
Andor CB2: A Next Generation High Speed CMOS Camera Platform for Wavefront Sensing — Solution Note
This article presents Andor CB2, a new camera platform improving upon the successful C-BLUE One family of high-speed CMOS cameras developed by First Light Imaging. Like C-BLUE One before it, CB2 is a…
Imaris 11 Webinar – Automate the Routine. Amplify the Insight — Webinars
Imaris 11 introduces Workflows, an intuitive and user-friendly protocol system designed for both experts and non-experts. Reproducibility is essential in research. Each…
Automated Microparticle Analysis with ParticleScout and Raman Microscopy — Application Notes
High-resolution measurements of particles are of great interest in many fields of application. Oxford Instruments' ParticleScout is an analysis tool for witec360 Raman microscopes that locates, cat…
RISE Microscopy for Pharma Research — Webinars
The development and production of drug delivery systems requires efficient and reliable control mechanisms to ensure the quality of the final products. These products can vary w…
Simple Automated Surface Roughness Measurements — Application Video
Surface roughness is one of the most common measurements made with AFM. While very useful, they can become tedious and time consuming when they need to be made repeatedly on mul…
X-Pulse 90: expanding the capabilities of benchtop NMR spectroscopy — Webinars
Benchtop nuclear magnetic resonance (NMR) spectrometers are more compact and lower in cost than their full-sized counterparts – that’s great news, but there’s …
A Graphical Guide to (EM)CCD Frame Rates and Readout Latency — Technical Article
Achieving high frame rates and minimising data transfer latency is necessary in many experiments and instruments that incorporate scientific imaging cameras. Frame rate is the speed at which consecut…
High-Speed Classification of Jurkat T-cells and CAL-1 Plasmacytoid Dendritic Cells using Broadband Coherent Anti-stokes Raman Spectroscopy (BCARS) — Application Notes
Coherent Raman scattering (CRS) techniques, such as Broadband Coherent Anti-Stokes Raman Spectroscopy (BCARS), have become increasingly valuable for label-free chemical analysis of biological samples…
Optical Diagnostics to Empower Fusion Reactor Development — Application Notes
Energy security is becoming increasingly important from both a civilian and national defense perspective. From a civilian point of view, energy resilience is coming under threat from the rise of AI c…
Detection Solutions for the Characterization and Development of Metasurfaces — Application Notes
Metasurfaces are class of metamaterials engineered to exert explicit control over the phase, amplitude, frequency, and polarization of electromagnetic radiation from radio frequencies to visible ligh…
Correlative imaging of 2D material heterostructures: Raman, Photoluminescence (PL) and Second Harmonic Generation (SHG) — Application Notes
Two-dimensional (2D) materials with remarkable electronic, optical, mechanical, and chemical properties attract attention in fundamental scientific research due to their great potential for industria…
Dendritic Spine Segmentation — Tutorials
In this tutorial, learn three methods for dendritic spine segmentation in Imaris 11.0: manual drawing and editing, automatic detection in the Filament wizard, and automatic dete…
Dedicated, Comprehensive and Fast Mineral Analysis with AZtecGeo — Application Notes
Electron microscopists and geoscientists have worked together to refine workflows for efficient whole-sample mineralogical characterisation. This collaboration led to the adaptation&nb…
Measuring Fat Content of Dairy Products by NMR — Application Notes
Method A variety of dairy products with a range of fat contents between 1% and 82% were analysed by NMR using an MQC-23 fitted with a 26 mm hydrogen probe. Analyses were conducted using the EasyCal …
Confocal Raman Imaging and Correlative Techniques in Life Science — Application Notes
Confocal Raman microscopy is a label-free and non-destructive technique that enables 2D and 3D measurements on biological samples both in vivo and in vitro. It can be seamlessly combined with other t…
Include a Manual Step in the Batch Analysis — Tutorials
Do you have an image analysis process that’s almost entirely automated, except for one step that must remain manual? Do you still want to run your analysis in Batch mode t…
Automate Your Analysis with Batch Mode and Compare Groups in Vantage — Tutorials
In this video, you’ll learn how to streamline your image analysis workflow by automating it with Workflows in Batch mode. Want to compare results across multiple experimen…
Use and Adjust an existing Workflow — Tutorials
Workflows can be created and shared with your colleagues and other researchers. You can also request a Workflow setup from our Technical & Application Support Team. In this …
Set Up, Execute and Share a Workflow — Tutorials
In this tutorial, you will learn how to organize your image analysis into Workflows. These Workflows can be exported and reused to efficiently analyze other similar images with …
SEM-BEX Mapping on Unprepared and Uncoated Samples: did we find the oldest extraterrestrial zircon? — Application Notes
Breakthroughs and Limitations of Element Mapping The ability to collect energy dispersive X-ray spectroscopy (EDS) data across a 2D plane revolutionized elemental analysis. This breakthrough allowed…
Laser-Induced Breakdown Spectroscopy (LIBS) for in-situ Fuel Retention Analysis in the Walls of Fusion Devices — Application Notes
Laser-Induced Breakdown Spectroscopy (LIBS) is an innovative atomic emission spectroscopy technique that enables real-time, in-situ elemental analysis of surfaces in harsh environments, making it ide…
Quality First: A Guide to SEM-EDS Feature Analysis with Ultim Max and AZtecFeature — Webinars
Unlock the full potential of your SEM with a quality first approach to feature analysis. This tutorial demonstrates how Ultim Max EDS detectors and AZtecFeature software combin…
Using BEX and EDS to Perform Qualitative and Quantitative Analysis of Micro-Segregation in Steel — Application Notes
Segregation—the uneven distribution of alloying elements or impurities in steel—is an unavoidable thermodynamic process that occurs during casting. As the alloy cools, element migration c…
Advanced SEM–EDS-BEX and Automated Mineralogy for the Characterisation and Processing of Rare Earth Element Resources — Application Notes
Rare Earth Elements (REEs) are critical to the performance of modern technologies, underpinning sectors from renewable energy generation and electric transport, to high-performance consumer electroni…
Routine Moiré Imaging of Twisted 2D Materials — Application Video
Many AFM manufacturers show moiré images of twisted 2D materials, but it is not evident how long these images take to acquire.  Oxford Instrument's hi…
How low can you go? Investigating the importance of pattern resolution in EBSD — Application Notes
The collection of the diffraction pattern from the sample is a critical step in the Electron Backscatter Diffraction (EBSD) workflow, but equally important is the process by which that pattern is…
Time Domain NMR in R&D: studying the properties of plant-based meat analogue burgers during “cooking process” — Application Notes
Meat analogue products based on plant protein sources have been widely considered a rich replacement for conventional meat. The main reason for the increased interest in meat analogues is public awar…
Raman Knowledge Base — Technical Article
Raman Basics How is the spatial resolution defined? The spatial resolution of a conventional wide-field as well as a confocal microscope is influenced by the numerical aperture (NA) of the objectiv…
Scintillators for Andor High Energy Detection Cameras — Application Notes
iKon-L HF CCD Best Resolution Best Throughput Scintillator Characteristics Spatial Resolution* Energy Range Scintillator Characteristics Spatial Resolution* Energy Range YAG;…
Imaging and Spectroscopy Tools to Understand Material Self-Healing Mechanisms — Technical Article
In the world of material science – how does one extend a material’s functional lifetime? The field of self-healing materials is pursuing one solution to this question as scientists and en…
RISE Microscopy for Biomineralization Studies — Webinars
Over the years biominerals have been refined by natural selection, leading to the unique forms and functions we observe today. These forms can be studied at high resolution usin…
TSV Plasma Polish Optimization and AFM characterization for Quantum Computing — Webinars
Check out our on-demand webinar showcasing how the Oxford Instruments Jupiter AFM was used to characterize sidewall roughness in through-silicon vias (TSVs)—a critical fac…
Investigating the Dynamics of Neural Injury Using the Dragonfly with the MicroPoint Ablation Laser — Application Notes
In the Kucenas Lab, we are fascinated by the cellular and molecular mechanisms that drive glial development. Using zebrafish (Danio rerio), coupled with genetic and pharmacological perturbation, sing…
Andor Solutions for Situational Awareness — Solution Note
Surveillance systems are critical to the operation of modern security services, providing situational awareness that supports strategic planning and tactical decision making alongside accurate detect…
Torsional Force Microscopy of Twisted 2D Materials — Application Video
Determining the twist angle of stacked 2D materials by imaging the moiré periodicity is a critical step in the fabrication and characterization of these materials. But so…
Energy Transfer in Quantum Dots — Application Notes
Solid-state light-emitting diodes (LEDs) emit nearly monochromatic light, yet seamless tuning of emission color throughout the visible region remains elusive. Color-converting powder phosphors are th…
Airborne SWIR Imaging for Surveillance and Situational Awareness — Solution Note
Modern security and surveillance technology is relied upon to deliver increasingly accurate situational awareness while remaining dynamic and autonomously adaptable in the field. As a result, airborn…
Jupiter Discovery Achieving Stable and Gentle Imaging using FFM Topography with AutoPilot — Application Video
See how Jupiter Discovery AFM does the hard work for you, performing a pre-scan to select the ideal setpoint and integral gain. The results on a polystyrene-polypropylene sample…
Vacuum Ultraviolet Emission and Ultraviolet Absorption Spectroscopy for High-temperature High-Speed Shock Tube Flows — Application Notes
Atmospheric re-entry results in intense heat flux onto the surface of the flight vehicle due to the high enthalpy of the surrounding flow field. A major source of uncertainty in predicting this heat …
Mapping Conjugation Pathways in Conducting Polymers with Raman Spectroscopy — Application Notes
Organic conjugated polymers have received significant attention in recent decades due to their use in several optoelectronic applications, including light-emitting diodes and solar cells.1 A crucial …
Mechanical Microscopy of Surface Treatments — Application Notes
Surface treatments, such as coatings, nitriding, and shot peening, are invaluable to industry as a method to improve the functional and mechanical behavior of parts without changing the primary mater…
In-Situ, High-Temperature Microcompression of Silicon — Application Notes
High temperature microcompression is an exciting application that allows uniaxial stress-strain behavior to be measured as a function of temperature for site-specific microstructural features: grains…
Mechanical Microscopy of Additively-Manufactured 316L Stainless Steels — Application Notes
Additive manufacturing of metal components is changing the way components are both designed and manufactured due to its capability to make complex geometries. However, additively-manufactured materia…
Correlated mechanical microscopy and EDS for compositional gradient samples — Application Notes
Compositional gradients are both a useful tool for combinatorial investigations and an industrial reality in high-temperature materials where diffusion can occur at service temperatures. In this appl…
Adhesion Measurement via Nanoindentation — Application Notes
Modern products increasingly utilize engineered surface functionalities to achieve superior performance, such as hydrophobicity for self-cleaning window glass. These properties result from tailored s…
Strain Rate and Nanoindentation — Application Notes
The deformation behavior of materials is often time dependent. During uniaxial mechanical testing at higher deformations speeds, most metals display higher strengths. This time dependence is called s…
Strain Rate Jump Nanoindentation Mapping — Application Notes
Mechanical microscopy is a flexible technology that allows numerous nanoindentation techniques to provide various imaging modalities to investigate the spatial distribution of different mechanical pr…
Correlated mechanical microscopy with EBSD for orientation-property relationships and anisotropy — Application Notes
Mechanical microscopy often provides mechanical images which clearly show grain structure and/or different phases within the microstructure. These can often be blindly deconvoluted using cluster anal…