New Frontiers in Myeloid Therapy: High-Resolution Insights into Rescuing the Diseased Brain

New Frontiers in Myeloid Therapy: High-Resolution Insights into Rescuing the Diseased Brain

Time: 11:00 a.m. EST | 2:00 p.m. PST

Many neurodegenerative diseases share a common driver: the failure of the brain’s immune system. This research uncovers a pre-symptomatic "interferon alarm" that triggers progressive decline and identifies a unique molecular signature for pathological cell aggregates. By utilizing high-resolution mapping and direct microglia replacement, researchers successfully normalized the brain's immune environment and doubled survival. This breakthrough establishes a powerful new blueprint for treating diverse and devastating neurological disorders

You will learn about:

• Discover how a direct, CNS-limited microglia replacement strategy achieved over 80% replacement of resident macrophages.
• Learn about the identification of an early interferon-stimulated gene (ISG) response that serves as a sentinel for neurodegeneration before clinical symptoms appear
• Explore how high-resolution confocal microscopy and 3D volumetric reconstruction were used to quantify the physical impact of the disease
• Understand how these findings in a rare leukodystrophy provide a scalable strategy for treating a wide array of monogenic and neurodegenerative disorders

A live Q&A session will follow the presentation, hosted by Dr. William H. Aisenberg, Postdoctoral Fellow at Bennet lab at the University of Pennsylvania, Perelman School of Medicine and Lynsey Hamilton, Market Development Specialist at Oxford Instruments .